Nineteen of the Russian's 21 titles have been earned on hard surfaces
A comeback the Russian player won his initial title for 882 days with success over opponent Moutet in the tournament final.
The athlete, a ex- number one, has endured a difficult period, winning just one win at the major tournaments and experiencing a meltdown at the New York tournament.
The player's unpredictability on the professional circuit - and struggles with his serving in especial - led to him falling of the world's top 10 and eventually separating with long-time mentor Cervara.
Presently training with his coach and his other coach, he has gradually progressed in the recent weeks - peaking in a hard-fought competitive victory over challenger Corentin Moutet.
This represents the player's initial title after the Rome competition and maiden on a hard surface since spring of the previous year.
Victory also indicates the Russian has won twenty-one titles at twenty-one distinct tournaments.
"For the first time I'm at a competition with my two daughters together, so to secure a title is particularly special," said ranked player Medvedev.
"This victory is in tribute of my younger daughter my daughter, because the initial championship I got when my older daughter Alisa was delivered was for her."
Medvedev, the 2021 US Open champion, had been defeated in his past six title deciders, comprising in that event earlier this year.
The player's retrieving approach and recurring reactions on court had caused commentators to wonder if his skill to compete at the elite level was over.
However the player has implemented adjustments in the past month, striving to advance forward and play positively, backed up by an better serve.
He fought back from a break down in the opening set against the difficult opponent, winning four of the concluding five points to take the lead.
The competitors swapped service breaks in the second set before the Frenchman, attempting for his first ATP Tour victory, gained dominance to push for a decider.
He defended 4 initial opportunities in a tight final set before Medvedev won the break to that score to serve for the match.
Appropriately, Medvedev clinched the win with a rally at the front of the court, with Moutet failing to handle a return after two hours and 38 minutes.